ARG3 — Aspergillus fumigatus

Summary

AFU4G07190 (ARG3, argB) encodes a protein with ornithine carbamoyltransferase and aspartate carbamoyltransferase activities, as well as carbamoyl-phosphate synthase (ammonia and glutamine-hydrolyzing) activities, glutaminase activity, amino acid binding, ATP binding, and metal binding. The gene is associated with citrulline, ornithine, arginine and siderophore biosynthesis, as well as de novo UMP and pyrimidine production, glutamine metabolism, the urea cycle, amino acid metabolic process, and nitric oxide storage. Its product localises to the cytoplasm, cytosol, nucleus, mitochondria, and mitochondrial lumen. In Aspergillus fumigatus, ARG3 is linked to invasive pulmonary aspergillosis and has been studied in Galleria mellonella and Mus musculus models. Associations with numerous phenotypes include altered cell death, replicative lifespan, mitochondrial transport, nutrient uptake, adhesion, pexophagy, mitophagy, pseudohyphal growth, sporulation efficiency, thermotolerance and carbon/nitrogen source utilisation. Studies of related genes in other species connect it to vegetative growth and colony appearance.