COQ2 — Aspergillus fumigatus

Summary

AFU4G05970, designated AfCOQ2, encodes a UbiA prenyltransferase family protein with 4-HB polyprenyltransferase activity (EC 2.5.1.39). The gene is associated with ubiquinone, isoprenoid, terpenoid, and lysine anabolism, as well as secondary metabolism including austinol, dehydroaustinol, and mycophenolic acid anabolism. It is linked to mitochondrial inner membrane localisation and processes such as mitochondrial fission, cell cycle modulation, mating, DNA damage response, protein synthesis, and homeostasis. Phenotypic associations include absent spore wall formation, abnormal flocculation, absent cytokinesis, abnormal septum formation, abnormal chitin deposition, abnormal pseudohyphal growth, and absent mitophagy, along with increased cell death, increased mitochondrial genome maintenance, and absent respiratory metabolism. The gene is also associated with delayed endocytosis and vacuolar transport, abnormal vesicle distribution, and increased nutrient uptake. Studies of related genes in other species link the family to oxidative stress response.