CLM2 — Aspergillus fumigatus

Summary

AFU4G02730 (symbol CLM2, also known as AfCLM2 and AfCYP51A) on chromosome 4 of Aspergillus fumigatus encodes a putative O-methylsterigmatocystin oxidoreductase belonging to the fungal cytochrome P450 family. The product exhibits oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen, monooxygenase activity, heme binding, and iron binding. It is associated with membrane localisation and linked to diverse biological processes including sterol homeostasis, asexual reproduction and sporulation, demethylation, fatty acid oxidation, DNA amplification, mitochondrial fission, and the inflammatory response. Phenotypic associations connect the gene to decreased micronucleophagy and ribophagy, increased cell death, arrested vegetative and exponential growth, abnormal cell cycle progression, decreased invasive growth, and altered nutrient and iron utilization. Related genes in other species link the family to sterol biosynthesis.