YHB1 — Aspergillus fumigatus

Summary

AFU4G03410 (YHB1, also known as fhpA) in Aspergillus fumigatus encodes a protein with globin and flavoprotein reductase domains, and is associated with nitric oxide dioxygenase [NAD(P)H] activity, oxygen binding, FAD binding, and heme binding. The gene is associated with nitric oxide breakdown, cellular response to nitrosative stress, alternative respiration, detoxification, siderophore and ergosterol anabolism, arginine metabolism, gluconeogenesis, filamentous growth of a population of unicellular organisms, and the mitotic cell cycle. It has been linked to invasive pulmonary aspergillosis and localized to mitochondria, cytoplasm, cytosol, and nucleus. Studies of related genes in other species connect the family to increased flocculation, absent pseudohyphal growth, decreased respiratory metabolism, increased autophagy, and decreased gamma ray resistance. The family has also been linked to reduced virulence in other fungi.