ERG6 — Aspergillus fumigatus

Summary

AFU4G03630 (ERG6) in Aspergillus fumigatus encodes a sterol 24-C-methyltransferase, a member of the Erg6/SMT methyltransferase family. The gene is associated with sterol homeostasis, zymosterol metabolic process, and ergosterol anabolism, as well as response to basic pH, oxidative phosphorylation, and cellular response to xenobiotic stimulus. Its product localises to the endoplasmic reticulum, mitochondria, plasma membrane, and adiposome. ERG6 is linked to invasive pulmonary aspergillosis and to numerous cellular phenotypes including abnormal filamentous growth, increased adhesion, decreased endocytosis, altered cell cycle progression, and increased polyploidy. Studies of related genes in other species connect the family to cell membrane stability, stress responses, and ion content traits.