IST2 — Aspergillus fumigatus

Summary

AFU4G02970 (IST2, TMEM16) in Aspergillus fumigatus encodes a putative plasma membrane channel protein (Aqy1) that belongs to the anoctamin family and is annotated as a voltage-sensitive calcium channel with phospholipid scramblase activity and metal binding. The gene is associated with phospholipid translocation, lipid transport, ion membrane transport, secretion, and membrane fusion. It is also associated with peristalsis, blood clotting, and phototransduction. The encoded protein localises to the endoplasmic reticulum, cortical ER, and EPCS (ER-plasma membrane contact sites). Related genes in other species link the family to plasma membrane channel function.