BCS1 — Aspergillus fumigatus

Summary

AFU4G01260 (BCS1, Bcs1) in Aspergillus fumigatus encodes a putative mitochondrial chaperone ATPase, possessing ATP hydrolase, metalloendopeptidase, and protein carrier activities. The gene is associated with mitochondrial cytochrome bc1 complex assembly, protein insertion into the mitochondrial membrane from the inner side, and mitochondrial protein quality control and processing. It is also linked to the ERAD pathway, proteasomal protein catabolic process, peroxisome matrix protein import, sporulation, and homeostasis. The encoded protein localizes to the mitochondrial inner and outer membranes, the M-AAA complex, and the peroxisome membrane. Phenotypic associations include absent respiratory metabolism and spore germination, decreased mitochondrial transport and cell cycle progression in S phase, increased mitochondrial rho- mutation frequency, and altered vegetative growth and pseudohyphal growth. Studies of related genes in other species link the BCS1 family to oxidative stress response and acid sensitivity.