PEP2 — Aspergillus fumigatus

Summary

AFU3G14810 (PEP2) on chromosome 3 of Aspergillus fumigatus encodes a putative pathogenesis-associated protein Pep2, which contains a SnoaL-like domain and an NTF2-like domain superfamily. The gene is annotated to biological processes including inflammatory response, immune response, amino acid anabolism, secretion, morphogenesis, and cell growth. Studies of related genes in other species link the PEP2 family to reduced virulence, and sequence similarity connects the gene to root rot and to Verticillium dahliae and Fusarium oxysporum. The encoded protein is also associated with a WW domain-containing protein and catabolic 3-dehydroquinase through distant sequence relationships.