ppoB — Aspergillus fumigatus

Summary

AFU4G00180 (ppoB) on Aspergillus fumigatus chromosome 4 encodes a putative fatty acid oxygenase with multiple catalytic activities, including linoleate 8R-lipoxygenase, 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase, fatty acid peroxidase, dioxygenase, monooxygenase, and general peroxidase and isomerase functions, and it binds heme and iron. The gene is associated with oxylipin and prostaglandin biosynthesis, long-chain fatty acid and carboxylic acid metabolism, hydrogen peroxide catabolism, and response to oxidative stress. It is linked to both positive regulation of asexual sporulation and conidiophore development, as well as negative regulation of sexual sporulation, and to penicillin and sterigmatocystin biosynthesis. Related genes in other species have been linked to reduced virulence.