encA — Aspergillus fumigatus

Summary

AFU4G00210 (encA) on Aspergillus fumigatus chromosome 4 encodes a fungal polyketide synthase (PKS) with ketoacyl-ACP synthase, fatty acid synthase, and phosphopantetheine binding activities, classified under EC 2.3.1.-. The protein contains multiple PKS domains including SAT, dehydratase, acyl transferase, ketoacyl synthase, and acyl carrier protein domains. This gene is associated with the biosynthesis of several secondary metabolites, including monodictyphenone, arugosin, o-orsellinic acid, emodin, endocrocin, shamixanthone, and sterigmatocystin, as well as fatty acid anabolism and general secondary metabolism. It has also been linked to neutrophil chemotaxis. Related genes in other species link the family to the protein ACAS in Drosophila and to unaffected pathogenicity.