CTA4 — Aspergillus fumigatus

Summary

AFU3G13790 (CTA4) in Aspergillus fumigatus encodes a P5A-type ATPase, a member of the P-type ATPase family with E1-E2 ATPase, P-type ATPase, cation-transporting ATPase, phosphatidylcholine flippase, phosphatidylethanolamine flippase, phosphatidylserine flippase, phosphatidylserine floppase, membrane protein dislocase, P-type manganese transporter, ABC-type manganese transporter, P-type calcium transporter, and ATPase-coupled intramembrane lipid carrier activities. The gene is associated with extraction of mislocalized protein from ER membrane, monoatomic cation transmembrane transport, calcium transport, endocytic recycling, manganese ion transport, cellular manganese ion homeostasis, post-Golgi transport, phospholipid translocation, calcium ion membrane transport, response to unfolded protein, cellular calcium ion homeostasis, protein targeting, macroautophagy, fungal-type cell wall organization, protein folding, spore formation, secretion, and protein transport. It localizes to the Cdc50p-Drs2p complex, trans-Golgi network membrane, TGN, nuclear envelope, fungal-type vacuole membrane, Golgi membrane, Golgi complex, ER membrane, ER, and plasmalemma. CTA4 has been linked to pulmonary aspergillosis and studied in Galleria mellonella and mouse models. Phenotypic associations include altered vacuolar transport, endocytosis, cell cycle progression, ch