ppoC — Aspergillus fumigatus

Summary

AFU3G12120 (symbol ppoC) on chromosome 3 of Aspergillus fumigatus encodes a protein with linoleate 8R-lipoxygenase, 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase, fatty acid peroxidase, and general peroxidase, dioxygenase, isomerase, monooxygenase, and oxidoreductase activities, and binds heme and iron. The gene is associated with oxylipin and prostaglandin biosynthesis, long-chain fatty acid and carboxylic acid metabolism, hydrogen peroxide catabolism, and response to oxidative stress. It is linked to both positive regulation of asexual sporulation and negative regulation of sexual sporulation, conidiophore development, pigmentation, and penicillin and sterigmatocystin metabolism. The gene has also been connected to aspergillosis. Studies of related genes in other species link the family to reduced virulence in some pathogens, though pathogenicity can remain unaffected.