OPT1 — Aspergillus fumigatus

Summary

AFU3G12200 (OPT1, optC) encodes an oligopeptide transporter of the OPT family, with tetrapeptide, oligopeptide and glutathione transmembrane transporter activity. It is associated with folate transport and biosynthesis, glutathione uptake, and protein transport, and localises to the plasma membrane at cell tips, the Golgi complex and ER membrane. The gene has been linked to numerous phenotypes including abnormal nutrient utilisation, increased cell death, increased lifespan, decreased colony size, abnormal cell wall morphology, increased desiccation resistance, decreased acquired thermotolerance, abnormal cell cycle progression, altered autophagy and mitophagy, increased aneuploidy, and abnormal respiratory metabolism. Studies of related genes in other species connect the family to pH response and acid sensitivity.