prtT — Aspergillus fumigatus

Summary

AFU3G12780 (symbol prtT) on chromosome 3 of Aspergillus fumigatus encodes a C6 transcription factor with a Zn2Cys6 DNA-binding domain and annotated DNA-binding transcription factor activity, RNA polymerase II-specific. The product localises to the nucleus. prtT is associated with proteolysis, protein breakdown, and oligopeptide transport, as well as with secretion and ergosterol anabolism. It is also linked to filamentous growth of a population of unicellular organisms in response to biotic stimulus, positive regulation of that growth, and cell death. Studies of related Zn(2)-C6 fungal-type domain-containing proteins in other species connect the gene family to similar regulatory roles, but these associations are not yet established for A. fumigatus.