ace2 — Aspergillus fumigatus

Summary

AFU3G11250 (ace2) in Aspergillus fumigatus encodes a putative C2H2 transcription factor (Swi5 family) with DNA-binding transcription activator activity, RNA polymerase II-specific, and 14-3-3 protein binding. It is associated with positive regulation of asexual sporulation and spore wall assembly, septum digestion after cytokinesis, and antisense RNA transcription. The gene is linked to cellular stress responses, including response to acid pH, calcium ions, and metals, as well as calcineurin-mediated signaling, pigmentation, biofilm formation, cell adhesion, and regulation of the apoptotic process. It localizes to the cytoplasm, cytosol, and nucleus. Studies of related genes in other species link the family to loss of pathogenicity and reduced virulence, though these associations are not established for A. fumigatus.