PGM1 — Aspergillus fumigatus

Summary

AFU3G11830, also known as PGM1 or pgmA in Aspergillus fumigatus on chromosome 3, encodes a phosphoglucomutase enzyme (EC 5.4.2.2) belonging to the alpha-D-phosphohexomutase superfamily. The gene is associated with phosphoglucomutase activity and magnesium binding. It is associated with the Leloir pathway, glucose and carbohydrate metabolism, biofilm formation, and cell growth. It localizes to both the cytosol and nucleus. Phenotypic associations include delayed sporulation, abnormal spore wall formation, decreased chitin deposition, increased aneuploidy, altered cell cycle progression, and sterile mating response. Carbon source utilization is delayed, while survival rate in stationary phase is increased. Related genes in other species link the family to similar metabolic and cell cycle processes.