MCB — Aspergillus fumigatus

Summary

AFU3G10000 (MCB, also known as pkaR) encodes a cAMP-dependent protein kinase regulatory subunit, a protein that contains a cyclic nucleotide-binding domain and is part of the cAMP-dependent protein kinase complex. The gene is associated with the regulation of asexual sporulation, hyphal growth, cell cycle progression, and carbohydrate storage, including glycogen anabolism. It has been linked to cellular responses to osmotic and oxidative stress, as well as to hypersensitivity and cell growth. Localisation evidence places the product in the cytosol and nucleus. Phenotypic associations include increased virulence, decreased spore germination rate, altered cell cycle progression through G2/M and anaphase, and abnormal chromosome segregation. Studies of related genes in other species link the family to pathogenicity and virulence, though these associations are not yet established in Aspergillus fumigatus.