CLM2 — Aspergillus fumigatus

Summary

AFU3G09530 (symbol CLM2, also known as AfERG11 and AfCYP51A) on Aspergillus fumigatus chromosome 3 encodes a fungal cytochrome P450 monooxygenase with heme and iron binding, acting on paired donors with oxygen incorporation. The gene is associated with sterol homeostasis, demethylation, fatty acid oxidation, asexual reproduction and sporulation, prenylation, protein farnesylation, mitochondrial fission, actin depolymerization, and DNA amplification. It is linked to the ER membrane and membrane localisation. Phenotypic associations include decreased micronucleophagy, nucleophagy, and ribophagy; absent hyperosmotic stress resistance; abnormal cell cycle progression; increased cell death; arrested vegetative and exponential growth; decreased invasive growth and shmoo formation; and increased lifespan. Related genes in other species include ERG11.