AUS1 — Aspergillus fumigatus

Summary

AFU3G09680 (symbol AUS1, preferred name AfAUS1) on Aspergillus fumigatus chromosome 3 encodes a putative ABC efflux transporter belonging to the ABCG family, with ATP-coupled transmembrane transporter activity and phosphatidylethanolamine, phosphatidylcholine, and phosphatidylserine floppase activities. The gene is associated with xenobiotic detoxification by transmembrane export across the plasma membrane, cellular response to xenobiotic stimulus, response to antibiotic and actidione, ergosterol anabolism, steroidogenesis, mating, cell growth, carbohydrate metabolism, and hypersensitivity. Its product localizes to the plasma membrane, membrane, and extracellular vesicles. Phenotypic associations include abnormal small molecule transport, increased sporulation rate, decreased cell death rate, altered vacuolar distribution and transport, delayed exit from G0, increased fermentative growth, and abnormal chronological and replicative lifespan. Studies of related genes in other species link the family to sterol transport.