dvrA — Aspergillus fumigatus

Summary

AFU3G09820 (symbol dvrA, also known as C2H059) on chromosome 3 of Aspergillus fumigatus encodes a C2H2-type zinc-finger protein with DNA-binding transcription activator activity and sequence-specific DNA binding. The gene is associated with regulation of single-species biofilm formation in or on a host organism, positive regulation of cell-substrate adhesion, and suppression by symbiont of host inflammatory response. It is linked to melanin biosynthesis, gluconeogenesis, response to starvation, and downregulation of filamentous growth in response to pH. The encoded protein localises to the nucleus, cytoplasm, and heterochromatin. Related genes in other species link the family to reduced virulence and conditions such as disseminated candidiasis and denture stomatitis.