sltA — Aspergillus fumigatus

Summary

AFU3G08010 (sltA) on chromosome 3 of Aspergillus fumigatus encodes a C2H2-type zinc finger transcription factor (Ace1 family) with DNA-binding and transcription regulatory activity. The gene is associated with the regulation of DNA-templated transcription, response to stress, maintenance of dormancy, invasive growth, ergosterol anabolism, proteolysis, and homeostasis. It is also linked to nitric oxide storage and localises to the nucleus. In trait associations, sltA has been connected to salt tolerance. Related genes in other species are linked to pulmonary aspergillosis, and the gene itself is associated with invasive pulmonary aspergillosis in a mouse model.