prx6 — Aspergillus fumigatus

Summary

AFU3G09480 (prx6) on chromosome 3 of Aspergillus fumigatus encodes a 15-hydroxyprostaglandin dehydrogenase (NAD(+)) belonging to the short-chain dehydrogenase/reductase (SDR) family, with 3-oxoacyl-ACP reductase activity and broader oxidoreductase activity acting on CH-OH groups with NAD or NADP as acceptor. The gene is associated with abscisic acid and terpenoid anabolism, secondary metabolite biosynthesis, and response to fungi. It is linked to oxidative stress response. The encoded protein localises to the membrane and cytoplasm. Studies of related genes in other species connect the SDR family to additional oxidoreductase activities, though these associations are not yet established for this specific gene.