AFU3G09320 — Aspergillus fumigatus

Summary

AFU3G09320, designated FOR (also known as AfSHM1 or AfSHM2) in Aspergillus fumigatus on chromosome 3, encodes a serine hydroxymethyltransferase (EC 2.1.2.1) with glycine hydroxymethyltransferase activity and pyridoxal phosphate binding, placing it in the Ser_HO-MeTrfase-like family. The gene is associated with tetrahydrofolate interconversion and metabolism, primary metabolism, hyphal growth, secretion, and excretion. It is linked to immune-related processes including defense response, immune response, IL-6 and IL-22 production, T cell activation, and metabolic burst. The encoded protein localizes to the cytoplasm, cytosol, mitochondria, and the fungal biofilm matrix. Related genes in other species connect the family to cell cycle progression, meiotic recombination, mitochondrial genome maintenance, and budding patterns, while the A. fumigatus gene itself is associated with colony size and cell size regulation.