rlmA — Aspergillus fumigatus

Summary

AFU3G08520 (symbol rlmA, also known as AfMADS003 or MADS003) in Aspergillus fumigatus chromosome 3 encodes a MADS-box transcription factor of the MEF2 type, with DNA-binding, bending, and RNA polymerase II-specific transcription regulatory activity. It is associated with DHN-melanin biosynthesis, cell wall organization, sporulation, invasive growth, and positive regulation of transcription. The gene has been connected to immune evasion, phagocytosis, upregulation of cell adhesion and flocculation, cellular stress response, and melanin anabolism. Its product localizes to the nucleus, nuclear envelope, chromatin, and cytosol. Related genes in other species link the family to oxidative stress response.