AUS1 — Aspergillus fumigatus

Summary

AFU3G07300 (AUS1) in Aspergillus fumigatus encodes an ABC transporter of the PDR/CDR subfamily, possessing ATP hydrolase activity and ATP binding. It is associated with steroidogenesis, ergosterol anabolism, xenobiotic detoxification via transmembrane export across the plasma membrane, mating, carbohydrate metabolism, hypersensitivity, and cell growth. The protein localises to the plasma membrane and membrane. Phenotypic associations include abnormal small molecule transport, increased sporulation rate, decreased cell death rate, delayed exit from G0, increased fermentative growth, abnormal replicative and chronological lifespan, and altered nutrient uptake, vacuolar distribution, and cell cycle progression. Studies of related genes in other species link the family to multidrug resistance and unaffected pathogenicity.