DAP2 — Aspergillus fumigatus

Summary

AFU3G07850 (DAP2) encodes a dipeptidyl-peptidase with serine-type peptidase and aminopeptidase activities, belonging to the peptidase S9B family. In Aspergillus fumigatus, this gene is associated with proteolysis, protein maturation, membrane transport, and the biosynthesis of monocarboxylic acids, sterols, ergosterol, and antibiotics. The encoded protein localizes to the vacuolar membrane and plasma membrane and is linked to endoplasmic reticulum localization and nuclear import. Phenotypic associations include abnormal cell cycle progression, decreased cell size, increased apoptosis, abnormal nuclear and spindle pole body positioning, defective budding, altered mitochondrial transport, and reduced mating efficiency. Studies of related genes in other species connect the family to sterility, decreased autophagy, and reduced anaerobic growth.