aspE — Aspergillus fumigatus

Summary

AFU3G07015 (aspE) on chromosome 3 of Aspergillus fumigatus encodes a septin, a member of the GTPase family that contains a G_SEPTIN domain and a P-loop NTPase domain. The gene product possesses GTPase activity, GTP binding, and bridging binding functions. It is associated with cytoskeleton-dependent cytokinesis, cell division, sporulation, morphogenesis, and protein localisation. The protein localises to the septin cytoskeleton, septin complex, septin ring, microtubule cytoskeleton, cell cortex, cell division site, and cross wall. The gene has been linked to invasive pulmonary aspergillosis in model organisms including Galleria mellonella and Mus musculus. Studies of related genes in other species connect the septin family to similar cellular processes.