anxc4 — Aspergillus fumigatus

Summary

The Aspergillus fumigatus gene AFU3G07020, symbol anxc4 on chromosome 3, encodes an annexin ANXC4 protein belonging to the annexin superfamily. The product exhibits calcium-dependent phospholipid binding, phosphatidylserine binding, and calcium ion binding activities. This gene is associated with sporulation. The protein localizes to the vesicle membrane, plasmalemma, cytoplasm, and nucleus. Studies of related genes in other species, including mouse ANX1, link the family to fungal meningitis and pathogenicity models in Galleria mellonella and Mus musculus, though these associations are not established for anxc4 itself.