ssd1 — Aspergillus fumigatus

Summary

AFU3G07150 (symbol ssd1) on chromosome 3 of Aspergillus fumigatus encodes a putative succinate-semialdehyde dehydrogenase, a member of the aldehyde dehydrogenase superfamily. The enzyme exhibits succinate-semialdehyde dehydrogenase (NADP+ and NAD+) activity, as well as acetaldehyde dehydrogenase (NAD+) activity. The gene is associated with GABA catabolism, polyamine breakdown, ethanol metabolism, acetaldehyde breakdown, threonine breakdown, and cellular detoxification of aldehyde. It is also linked to mycose biosynthesis, chitin biosynthesis, carbon catabolite activation of transcription, mRNA processing, cellular osmotic response, immune response, and homeostasis. The encoded protein localises to the mitochondrial lumen, Golgi complex, cytoplasm, cytosol, nucleus, and extracellular space. Related genes in other species link the family to broader aldehyde dehydrogenase functions.