FLUG — Aspergillus fumigatus

Summary

AFU3G07140 (FLUG, fluG) in Aspergillus fumigatus chromosome 3 encodes the extracellular developmental signal biosynthesis protein FluG, a member of the glutamine synthetase and amidohydrolase families with glutamine synthetase and hydrolase activities. This gene is associated with developmental induction, positive regulation of conidium formation, asexual reproduction and sporulation, as well as sporocarp development involved in asexual reproduction. It is linked to the regulation of sterigmatocystin and aflatoxin biosynthetic processes, secondary metabolism, sterol metabolism, autolysis, and hyphal growth. The protein localizes to the cytoplasm. Studies of related genes in other species link the FluG family to oxidative stress response.