hacA — Aspergillus fumigatus

Summary

AFU3G04070, designated hacA on Aspergillus fumigatus chromosome 3, encodes a bZIP transcription factor of the Hac1/HY5 family with DNA-binding transcription factor activity specific to RNA polymerase II. The gene is associated with the unfolded protein response, including ER stress response, the ERAD pathway, and intracellular signal transduction. It is linked to protein folding, secretion, hyphal growth, spore germination, and positive regulation of transcription by RNA polymerase II. The product localises to the nucleus. Studies of related genes in other species link the family to reduced virulence and associations with skin and nail infections.