sidE — Aspergillus fumigatus

Summary

AFU3G03350 (symbol sidE, also known as AfCHRY1 or CHRY1) on Aspergillus fumigatus chromosome 3 encodes a protein with domains including an adenylation domain, condensation domain, and phosphopantetheine attachment site, and exhibits ligase, isomerase, and phosphopantetheine binding activities. The gene is associated with nonribosomal peptide, emericellamide, and siderophore biosynthesis, as well as amino acid activation for nonribosomal peptide production, secondary metabolism, cellular response to iron ion starvation, immune evasion, and small molecule metabolism. Its product localizes to the cytoplasm. Studies of related genes in other species, including Fusarium species, link the family to similar secondary metabolite pathways, though these associations are not established for this specific gene.