CI-1 — Aspergillus fumigatus

Summary

AFU3G03450 (CI-1) in Aspergillus fumigatus encodes a putative cytochrome P450 oxidoreductase, a monooxygenase with heme and iron binding that acts on paired donors with incorporation of molecular oxygen (EC 1.14.-.-). The gene is associated with the biosynthesis of ergosterol, sterols, melanin, and several secondary metabolites including griseofulvin, mycophenolic acid, and cichorine. It is linked to the endoplasmic reticulum membrane. Phenotypic associations include increased fermentative growth, decreased endocytosis, abnormal autophagy, decreased meiosis, increased cell death, abnormal cytoskeleton and mitochondrial morphology, decreased colony size, and arrested vegetative growth. Related genes in other species have been linked to potassium concentration and acid sensitivity.