sidF — Aspergillus fumigatus

Summary

AFU3G03400 (sidF) on Aspergillus fumigatus chromosome 3 encodes an acyltransferase of the MbtK/IucB-like family, with acyl-CoA acyltransferase activity (EC 2.3.1.-, GO:0016410). The gene is associated with siderophore and ferrichrome anabolism, reductive iron assimilation, N',N'',N'''-triacetylfusarinine C anabolism, ergosterol anabolism, asexual sporulation, germ tube formation, protein import, and NO storage. Its product localises to the peroxisome, cytosol, and nucleus. Studies of related genes in other species link the family to reduced virulence, with sequence similarity to aerobactin siderophore biosynthesis protein iucB.