ABC2 — Aspergillus fumigatus

Summary

AFU3G03430 (ABC2, also known as sitT) encodes an ABC multidrug transporter SitT, a member of the type I exporter family with ATP-binding cassette domains and ATP hydrolase activity. The gene is associated with ABC-type oligopeptide transporter and ATP-coupled transmembrane transporter activities, and is linked to D-amino acid metabolism, glutathione metabolism, oligopeptide export from mitochondria, autophagy, membrane transport, and homologous recombination. It localises to the mitochondrial inner membrane, plasmalemma, and membrane. Phenotypic associations include altered oxidative and osmotic stress resistance, abnormal vacuolar morphology and distribution, increased pexophagy, decreased endocytosis, abnormal cell cycle progression, and changes in protein/peptide accumulation. Studies of related genes in other species link the family to oxidative stress response.