NPS6 — Aspergillus fumigatus

Summary

AFU3G03420 (symbol NPS6, also known as sidD) on chromosome 3 of Aspergillus fumigatus encodes a protein with adenylation, condensation, and phosphopantetheine-binding domains and exhibits SAM-dependent methyltransferase and ligase activities. The gene is associated with nonribosomal peptide and siderophore biosynthesis, specifically the production of N',N'',N'''-triacetylfusarinine C, as well as gliotoxin and ergosterol biosynthesis. It is linked to reductive iron assimilation, cellular responses to iron starvation, nitric oxide storage, germ tube formation, asexual sporulation, phagocytosis, and immune evasion. The encoded product localizes to the cytoplasm. Related genes in other species link the family to reduced virulence and associations with plant diseases including fusarium head blight, southern corn leaf blight, and brown spot.