CATB — Aspergillus fumigatus

Summary

AFU3G02270, symbol CATB and also known as cat1, CAT-3, AfCAT-3 or AfCATB on Aspergillus fumigatus chromosome 3, encodes a clade 2 catalase with catalase activity (EC 1.11.1.6), heme binding and metal binding. This gene is associated with detoxification of hydrogen peroxide, the cellular response to hydrogen peroxide and oxidative stress, as well as the immune response, metabolic burst, autolysis, asexual reproduction and sporulation, including conidia formation and regulation of morphogenesis. It has been linked to melanin anabolism, secondary metabolism, nucleotide anabolism, developmental processes, and cellular responses to heat and iron ion starvation. The product localises to the ascospore wall, peroxisomal lumen, cytosol and extracellular space. Related genes in other species link the family to oxidative stress response.