atrR — Aspergillus fumigatus

Summary

AFU3G02160 (atrR) on chromosome 3 of Aspergillus fumigatus encodes a C6 transcription factor with a Zn2Cys6 DNA-binding domain, conferring sequence-specific DNA binding and RNA polymerase II transcription factor activity. The gene is associated with siderophore anabolism, reductive iron assimilation, sterol and ergosterol anabolism, sterol homeostasis, biofilm formation, hyphal growth, hypersensitivity, and positive regulation of transcription. Its product localises to the nucleus, membrane, and cytosol. Studies of related genes in other species link the AtrR family to reduced virulence and pulmonary aspergillosis.