CAT1 — Aspergillus fumigatus

Summary

AFU2G18030 (CAT1) in Aspergillus fumigatus encodes a catalase enzyme with haem binding and metal binding activities, belonging to the catalase clade 1/3 family. The gene is associated with hydrogen peroxide detoxification and response, as well as autolysis, asexual reproduction, sporulation, morphogenesis, and secondary metabolism including fumigaclavine C and melanin biosynthesis. The catalase localises to peroxisomes, mitochondria, and cytoplasm. Phenotypic associations include increased pexophagy, decreased fermentative metabolism, increased entry into stationary phase, increased survival rate in stationary phase, increased ionic stress resistance, and sterility. The gene is also linked to decreased mitochondrial transport, decreased anaerobic growth, and increased mutation frequency. Related genes in other species connect the family to oxidative stress response.