dmaW — Aspergillus fumigatus

Summary

AFU2G18040 (symbol dmaW) in Aspergillus fumigatus chromosome 2 encodes a tryptophan dimethylallyltransferase (EC 2.5.1.34) with prenyltransferase activity, belonging to the DMATS-type aromatic prenyltransferase family. The gene is associated with alkaloid anabolism, specifically ergot alkaloid, fumigaclavine C, and indole alkaloid anabolism, as well as prenylation and methylation. It is linked to invasive pulmonary aspergillosis and to Danio rerio and Mus musculus. Studies of related genes in other species, including dmaW1, dmaW2, and cnsF, connect the family to similar alkaloid pathways, though these associations are not yet established for this specific gene.