AUS1 — Aspergillus fumigatus

Summary

AFU3G01400 (AUS1, abcH) on Aspergillus fumigatus chromosome 3 encodes an ABCG-type pleiotropic drug resistance (PDR) transporter with ATP-binding cassette domains and ATP hydrolase activity. The gene is associated with ATP-coupled transmembrane transporter activity, xenobiotic detoxification by transmembrane export across the plasma membrane, and response to antibiotic. It is associated with steroidogenesis, ergosterol anabolism, mating, carbohydrate metabolism, cell growth, and hypersensitivity. The product localises to the plasma membrane. Phenotypic associations include abnormal small molecule transport, increased sporulation rate, decreased cell death rate, abnormal chronological lifespan, altered nutrient uptake, and abnormal pseudohyphal growth. Related genes in other species link the family to multidrug resistance and sterol transport, while distant sequence similarity connects the family to plant traits such as leaf number, plant height, root length, and drought tolerance.