bgt2 — Aspergillus fumigatus

Summary

AFU3G00270 (bgt2) on chromosome 3 of Aspergillus fumigatus encodes a glycoside hydrolase family 17 protein with glucanosyltransferase activity, specifically 1,3-beta-glucanosyltransferase, glucan exo-1,3-beta-glucosidase, and glucan endo-1,3-beta-D-glucosidase activities (EC 3.2.1.39). The gene is associated with cell wall assembly and organization, fungal-type cell wall organization, morphogenesis, polysaccharide breakdown, and carbohydrate metabolism. It is linked to single-species biofilm formation both on host organisms and on inanimate substrates, as well as adhesion of symbiont to host and interaction with host. The product localizes to the yeast-form cell wall, fungal-type cell wall, side of membrane, extracellular vesicle, plasmalemma, cytoplasm, and extracellular space. Studies of related genes in other species connect the family to glucan endo-1,3-beta-D-glucosidase activity (EC 3.2.1.58).