fgaOx3 — Aspergillus fumigatus

Summary

AFU2G17960 (fgaOx3) on Aspergillus fumigatus chromosome 2 encodes an oxidoreductase with NADPH dehydrogenase activity, acting on CH-NH and CH-CH groups with NAD or NADP as acceptor, and binds FMN. The protein contains Oye-like, OxRdtase_FMN_N, and Aldolase_TIM domains. This gene is associated with secondary metabolism, specifically alkaloid anabolism, including ergot alkaloid, fumigaclavine C, and indole alkaloid anabolism, as well as alkaloid metabolism. It is also linked to biofilm formation. The encoded product localizes to the cytosol. Studies of related genes in other species connect the family to similar oxidoreductase functions in alkaloid pathways, though these associations are not yet established for fgaOx3 itself.