fgaFS — Aspergillus fumigatus

Summary

AFU2G17970 (symbol fgaFS) on Aspergillus fumigatus chromosome 2 encodes a protein belonging to the ergot alkaloid biosynthesis family, with oxidoreductase activity acting on the CH-NH group of donors using NAD or NADP as acceptor (EC 1.5.1.44). The gene is associated with alkaloid anabolism, specifically ergot alkaloid and fumigaclavine C anabolism, as well as indole alkaloid anabolism. Studies of related genes in other species link the family to similar oxidoreductase functions (EC 1.5.1.46) and ergot alkaloid biosynthetic processes. The encoded product also contains an Ig-like domain and a NAD(P)-binding domain superfamily, consistent with its redox activity.