SDH1 — Aspergillus fumigatus

Summary

AFU2G17580 (symbol SDH1, also known as arp1) on Aspergillus fumigatus chromosome 2 encodes a scytalone dehydratase (EC 4.2.1.94) with lyase activity and metal binding. This enzyme is associated with DHN-melanin biosynthesis, melanin metabolism, and pigmentation, as well as L-phenylalanine breakdown, immune evasion, conidia formation, sporulation, hyphal growth, and homologous recombination. The protein localises to the endosome. Studies of related genes in other species link the family to loss of pathogenicity and reduced virulence.