SSN8 — Aspergillus fumigatus

Summary

AFU2G15790 (SSN8, also known as AfSSN8 or SRB11) on chromosome 2 of Aspergillus fumigatus encodes a cyclin-like protein with cyclin-dependent protein serine/threonine kinase regulator activity. The gene is associated with the mediator complex and nucleus, and has been linked to regulation of transcription by RNA polymerase II, including positive regulation, as well as DNA-dependent transcription, glycan biosynthesis, and biofilm formation. Phenotypic associations include abnormal flocculation, absent or decreased biofilm formation, increased gamma ray resistance, decreased spore germination rate, increased adhesion, and altered cell cycle progression, including delayed passage through START and the metaphase-anaphase transition. The gene is also associated with decreased utilization of nitrogen sources, increased freeze-thaw resistance, and altered endocytosis. Studies of related genes in other species link the family to oxidative stress response, phosphate content, and zinc sensitivity.