mrr1 — Aspergillus fumigatus

Summary

AFU2G16860 (symbol mrr1) in Aspergillus fumigatus chromosome 2 encodes a putative MFS multidrug transporter, a member of the major facilitator superfamily. The gene product is annotated with spermidine and spermine transmembrane transporter activities and is associated with spermine transmembrane transport and general membrane transport. The protein localises to the fungal-type vacuole, Golgi complex, endoplasmic reticulum and plasmalemma. Studies of related genes in other species link the MFS transporter family to reduced virulence, though this association is not yet established for A. fumigatus.