ANP1 — Aspergillus fumigatus

Summary

AFU2G15910 (symbol ANP1, preferred name AfANP1) in Aspergillus fumigatus chromosome 2 encodes a putative mannan polymerase II complex ANP1 subunit with 1,6-alpha-mannosyltransferase activity. The gene is associated with mannan, galactomannan and cell wall mannoprotein biosynthesis, protein N-linked glycosylation, fungal-type cell wall organization, filamentous growth, and cellular responses to heat, biotic stimuli and xenobiotic stimuli. The encoded product localizes to the mannan polymerase II complex, cis-Golgi network, Golgi complex and endoplasmic reticulum. ANP1 has been linked to numerous phenotypes including altered spore germination, cell cycle progression, budding, septum formation, cell wall morphology, chitin deposition, protein secretion, endocytosis, nuclear transport, vacuolar transport, flocculation, vegetative growth rate, lifespan, UV resistance, hyperosmotic stress resistance, iron utilization, mitophagy and autophagy. Related genes in other species link the family to acid sensitivity and oxidative stress response.