AUS1 — Aspergillus fumigatus

Summary

AFU2G15130 (AUS1, also known as abcA) encodes a ABC transporter of the PDR/CDR subfamily with ATP hydrolase activity and azole ABC transporter activity. In Aspergillus fumigatus, this gene is associated with steroidogenesis, ergosterol anabolism, xenobiotic detoxification, response to toxic substances, homologous recombination, mating, carbohydrate metabolism, cell growth, and hypersensitivity. It has been linked to invasive pulmonary aspergillosis and Galleria mellonella. The gene is associated with abnormal small molecule transport, increased sporulation rate, decreased cell death, altered nutrient uptake, and abnormal replicative and chronological lifespan. Related genes in other species link the family to reduced virulence, drought tolerance, and oxidative stress response, though these associations are not established for AUS1 itself.