hapB — Aspergillus fumigatus

Summary

AFU2G14720 (symbol hapB) on chromosome 2 of Aspergillus fumigatus encodes a member of the NFYA domain family, a DNA-binding transcription activator with RNA polymerase II-specific activity and promoter-enhancer loop anchoring activity. The gene is associated with the CCAAT-binding factor complex, localises to the nucleus and heterochromatin, and is linked to the regulation of transcription by RNA polymerase II, including positive regulation. It is associated with carbohydrate anabolism and its regulation, the TCA cycle, regulation of aerobic respiration, sterol and ergosterol anabolism, pseurotin A anabolism, asexual reproduction, hyphal growth, signal transduction, and autophagy. Studies of related genes in other species link the gene family to oxidative stress response.